New Delhi, Dec 25 || In a significant breakthrough, US researchers have found in animal studies that Alzheimer's disease can be reverse, challenging previous studies that for over a century considered the neurodegenerative disease to be irreversible.
The new study, published in the journal Cell Reports Medicine and based on diverse preclinical mouse models and human Alzheimer's brains, demonstrated that maintaining proper NAD+ balance can prevent and even reverse the disease.
NAD+ is a central cellular energy molecule and a major driver of Alzheimer's.
The team also showed that the decline in NAD+ is even more severe in the brains of people with Alzheimer's, and that this also occurs in mouse models of the disease.
"We were very excited and encouraged by our results," said Andrew A. Pieper, senior author of the study and Director of the Brain Health Medicines Center, Harrington Discovery Institute at University Hospitals.